Interactions between tafenoquine and artemisinin-combination therapy partner drug in asexual and sexual stage Plasmodium falciparum.
Int J Parasitol Drugs Drug Resist
; 7(2): 131-137, 2017 08.
Article
em En
| MEDLINE
| ID: mdl-28319724
ABSTRACT
The 8-aminoquinoline tafenoquine (TFQ), a primaquine derivative, is currently in late-stage clinical development for the radical cure of P. vivax. Here drug interactions between TFQ and chloroquine and six artemisinin-combination therapy (ACT) partner drugs in P. falciparum asexual stages and gametocytes were investigated. TFQ was mostly synergistic with the ACT-partner drugs in asexual parasites regardless of genetic backgrounds. However, at fixed ratios of 13, 11 and 31, TFQ only interacted synergistically with naphthoquine, pyronaridine and piperaquine in gametocytes. This study indicated that TFQ and ACT-partner drugs will likely have increased potency against asexual stages of the malaria parasites, whereas some drugs may interfere with each other against the P. falciparum gametocytes.
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
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Artemisininas
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Sinergismo Farmacológico
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Aminoquinolinas
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Antimaláricos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article