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Do Memory B Cells Form Secondary Germinal Centers? Impact of Antibody Class and Quality of Memory T-Cell Help at Recall.
McHeyzer-Williams, Louise J; Dufaud, Chad; McHeyzer-Williams, Michael G.
Afiliação
  • McHeyzer-Williams LJ; The Scripps Research Institute, La Jolla, California 92037.
  • Dufaud C; The Scripps Research Institute, La Jolla, California 92037.
  • McHeyzer-Williams MG; The Scripps Research Institute, La Jolla, California 92037.
Article em En | MEDLINE | ID: mdl-28320753
ABSTRACT
Antigen recall can clearly induce a germinal center (GC) reaction. What has become an issue for debate are the origins of the antigen-specific B cells that form memory-response GCs (mGCs). Using antigen labeling and adoptive transfer, memory B cells expressing different antibody class can give rise to mGCs with differing efficiency. Here, we will argue that the range of class-specific memory responses reported across multiple systems represents the spectrum of memory B-cell fate and function. While the formulation of recall immunogen and location of mGCs have an important role, we propose that effective cognate regulation is the key variable influencing recall outcome. These issues remain central to contemporary efforts of rational vaccine design.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Centro Germinativo / Memória Imunológica Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Centro Germinativo / Memória Imunológica Idioma: En Ano de publicação: 2018 Tipo de documento: Article