Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence.

Farnsworth, Christopher W; Schott, Eric M; Jensen, Sarah E; Zukoski, Jacob; Benvie, Abigail M; Refaai, Majed A; Kates, Stephen L; Schwarz, Edward M; Zuscik, Michael J; Gill, Steven R; Mooney, Robert A

Farnsworth, Christopher W; Schott, Eric M; Jensen, Sarah E; Zukoski, Jacob; Benvie, Abigail M; Refaai, Majed A; Kates, Stephen L; Schwarz, Edward M; Zuscik, Michael J; Gill, Steven R; Mooney, Robert A.

Afiliação

Farnsworth CW; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Schott EM; Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Jensen SE; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Zukoski J; Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Benvie AM; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Refaai MA; Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Kates SL; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Schwarz EM; Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Zuscik MJ; Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Gill SR; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Mooney RA; Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.

Infect Immun ; 85(6)2017 06.

Article em En | MEDLINE | ID: mdl-28320836

Assuntos

Coagulase/metabolismo; Diabetes Mellitus Tipo 2/complicações; Obesidade/complicações; Osteomielite/patologia; Infecções Estafilocócicas/microbiologia; Abscesso/patologia; Animais; Anticorpos Antibacterianos/genética; Anticorpos Antibacterianos/metabolismo; Coagulase/genética; Diabetes Mellitus Tipo 2/microbiologia; Modelos Animais de Doenças; Fibrinogênio/metabolismo; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Obesidade/microbiologia; Osteomielite/microbiologia; Análise de Sequência de RNA; Ativação Transcricional; Regulação para Cima; Virulência

Palavras-chave

Staphylococcus aureus; clumping factor A; fibrinogen; obesity; osteomyelitis; type 2 diabetes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteomielite / Infecções Estafilocócicas / Coagulase / Diabetes Mellitus Tipo 2 / Obesidade Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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