Cortical complexity in bipolar disorder applying a spherical harmonics approach.
Psychiatry Res Neuroimaging
; 263: 44-47, 2017 May 30.
Article
em En
| MEDLINE
| ID: mdl-28324693
ABSTRACT
Recent studies using surface-based morphometry of structural magnetic resonance imaging data have suggested that some changes in bipolar disorder (BP) might be neurodevelopmental in origin. We applied a novel analysis of cortical complexity based on fractal dimensions in high-resolution structural MRI scans of 18 bipolar disorder patients and 26 healthy controls. Our region-of-interest based analysis revealed increases in fractal dimensions (in patients relative to controls) in left lateral orbitofrontal cortex and right precuneus, and decreases in right caudal middle frontal, entorhinal cortex, and right pars orbitalis, and left fusiform and posterior cingulate cortices. While our analysis is preliminary, it suggests that early neurodevelopmental pathologies might contribute to bipolar disorder, possibly through genetic mechanisms.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lobo Parietal
/
Transtorno Bipolar
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Lobo Frontal
/
Giro do Cíngulo
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article