Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles.
Med Mycol
; 56(1): 121-124, 2018 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-28340159
ABSTRACT
We studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wroclaw, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole and harbored no Cyp51A alterations. The study confirms the presence of azole resistant A. fumigatus strains in Poland at a level that is comparative to other European countries.
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Base de dados:
MEDLINE
Assunto principal:
Aspergilose
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Aspergillus fumigatus
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Triazóis
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Farmacorresistência Fúngica
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Antifúngicos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article