Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway.
Biochem Biophys Res Commun
; 486(3): 774-780, 2017 05 06.
Article
em En
| MEDLINE
| ID: mdl-28343995
ABSTRACT
Ischemia/reperfusion (I/R) induces additional damage to the restoration of blood flow to ischemic myocardium. This study examined the effects of urolithin A (UA) on myocardial injury of ischemia/reperfusion in vivo and vitro and explored its underlying mechanisms. Mice were subjected to myocardial ischemia followed by reperfusion. Cells were subjected to hypoxia followed by reoxygenation. UA alleviated hypoxia/reoxygenation (H/R) injury in myocardial cells, reduced myocardial infarct size and cell death in mice after ischemia/reperfusion. Meanwhile, UA enhanced antioxidant capacity in cardiomyocytes following hypoxia/reoxygenation. UA reduced myocardial apoptosis following ischemia/reperfusion. The protection of UA was abolished by LY294002, a PI3K/Akt-inhibitor. These results demonstrated that UA alleviates myocardial ischemia/reperfusion injury probably through PI3K/Akt pathway.
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MEDLINE
Assunto principal:
Cardiotônicos
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Traumatismo por Reperfusão Miocárdica
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Cumarínicos
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Miócitos Cardíacos
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Proteínas Proto-Oncogênicas c-akt
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Inibidores de Fosfoinositídeo-3 Quinase
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article