Immunological profiling of molecularly classified high-risk endometrial cancers identifies <i>POLE</i>-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition.

Eggink, Florine A; Van Gool, Inge C; Leary, Alexandra; Pollock, Pamela M; Crosbie, Emma J; Mileshkin, Linda; Jordanova, Ekaterina S; Adam, Julien; Freeman-Mills, Luke; Church, David N; Creutzberg, Carien L; De Bruyn, Marco; Nijman, Hans W; Bosse, Tjalling

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition.

Eggink, Florine A; Van Gool, Inge C; Leary, Alexandra; Pollock, Pamela M; Crosbie, Emma J; Mileshkin, Linda; Jordanova, Ekaterina S; Adam, Julien; Freeman-Mills, Luke; Church, David N; Creutzberg, Carien L; De Bruyn, Marco; Nijman, Hans W; Bosse, Tjalling.

Afiliação

Eggink FA; Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen , Groningen, the Netherlands.
Van Gool IC; Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.
Leary A; Department of Medical Oncology, INSERM U981, Gustave Roussy Cancer Center , Villejuif, France.
Pollock PM; Queensland University of Technology (QUT), Translational Research Institute , Brisbane, QLD, Australia.
Crosbie EJ; Institute of Cancer Sciences, University of Manchester, St Marys Hospital , Manchester, UK.
Mileshkin L; Division of Cancer Medicine, Peter MacCallum Cancer Centre , East Melbourne, VIC, Australia.
Jordanova ES; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands; Center for Gynecological Oncology Amsterdam, VU Medical Center, Amsterdam, the Netherlands.
Adam J; Department of Medical Oncology, INSERM U981, Gustave Roussy Cancer Center , Villejuif, France.
Freeman-Mills L; Tumour Genomics and Immunology Group, Oxford Centre for Cancer Gene Research, The Wellcome Trust Centre for Human Genetics, University of Oxford , Oxford, UK.
Church DN; Tumour Genomics and Immunology Group, Oxford Centre for Cancer Gene Research, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Oxford Cancer Centre, Churchill Hospital, Oxford, UK.
Creutzberg CL; Department of Clinical Oncology, Leiden University Medical Center , Leiden, the Netherlands.
De Bruyn M; Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen , Groningen, the Netherlands.
Nijman HW; Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen , Groningen, the Netherlands.
Bosse T; Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.