Deferasirox pharmacogenetic influence on pharmacokinetic, efficacy and toxicity in a cohort of pediatric patients.

Allegra, Sarah; De Francia, Silvia; Cusato, Jessica; Arduino, Arianna; Massano, Davide; Longo, Filomena; Piga, Antonio; D'Avolio, Antonio

Allegra, Sarah; De Francia, Silvia; Cusato, Jessica; Arduino, Arianna; Massano, Davide; Longo, Filomena; Piga, Antonio; D'Avolio, Antonio.

Afiliação

Allegra S; Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, 10149 Turin, Italy.
De Francia S; Department of Biological & Clinical Sciences, S Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano (TO), Italy.
Cusato J; Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, 10149 Turin, Italy.
Arduino A; Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, 10149 Turin, Italy.
Massano D; Department of Biological & Clinical Sciences, S Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano (TO), Italy.
Longo F; Department of Biological & Clinical Sciences, S Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano (TO), Italy.
Piga A; Department of Biological & Clinical Sciences, S Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano (TO), Italy.
D'Avolio A; Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, 10149 Turin, Italy.

Pharmacogenomics ; 18(6): 539-554, 2017 Apr.

Article em En | MEDLINE | ID: mdl-28346059

Assuntos

Benzoatos; Quelantes de Ferro; Variantes Farmacogenômicos; Polimorfismo de Nucleotídeo Único; Triazóis; Talassemia beta/tratamento farmacológico; Adolescente; Benzoatos/sangue; Benzoatos/uso terapêutico; Benzoatos/toxicidade; Criança; Pré-Escolar; Estudos de Coortes; Deferasirox; Feminino; Humanos; Quelantes de Ferro/farmacocinética; Quelantes de Ferro/uso terapêutico; Quelantes de Ferro/toxicidade; Masculino; Testes Farmacogenômicos; Triazóis/sangue; Triazóis/uso terapêutico; Triazóis/toxicidade; Talassemia beta/genética; Talassemia beta/metabolismo

Palavras-chave

BCRP1; CYP1A1; CYP1A2; CYP2D6; LIC; SNP; creatinine; ferritin; iron overload; ß-thalassemia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Benzoatos / Quelantes de Ferro / Talassemia beta / Polimorfismo de Nucleotídeo Único / Variantes Farmacogenômicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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