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Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
Beg, Muhammad Shaalan; Huang, Xiumei; Silvers, Molly A; Gerber, David E; Bolluyt, Joyce; Sarode, Venetia; Fattah, Farjana; Deberardinis, Ralph J; Merritt, Matthew E; Xie, Xian-Jin; Leff, Richard; Laheru, Daniel; Boothman, David A.
Afiliação
  • Beg MS; Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Huang X; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Silvers MA; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Gerber DE; Departments of Pharmacology and Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Bolluyt J; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Sarode V; Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Fattah F; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Deberardinis RJ; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Merritt ME; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Xie XJ; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Leff R; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Laheru D; Departments of Pharmacology and Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Boothman DA; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.
J Surg Oncol ; 116(1): 83-88, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28346693

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Naftoquinonas / NAD(P)H Desidrogenase (Quinona) Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Naftoquinonas / NAD(P)H Desidrogenase (Quinona) Idioma: En Ano de publicação: 2017 Tipo de documento: Article