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Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1.
Hansen, Joshua D; Condroski, Kevin; Correa, Matthew; Muller, George; Man, Hon-Wah; Ruchelman, Alexander; Zhang, Weihong; Vocanson, Fan; Crea, Tim; Liu, Wei; Lu, Gang; Baculi, Frans; LeBrun, Laurie; Mahmoudi, Afshin; Carmel, Gilles; Hickman, Matt; Lu, Chin-Chun.
Afiliação
  • Hansen JD; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Condroski K; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Correa M; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Muller G; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Man HW; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Ruchelman A; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Zhang W; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Vocanson F; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Crea T; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Liu W; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Lu G; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Baculi F; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • LeBrun L; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Mahmoudi A; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Carmel G; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Hickman M; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
  • Lu CC; Celgene Corporation , 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States.
J Med Chem ; 61(2): 492-503, 2018 01 25.
Article em En | MEDLINE | ID: mdl-28358507
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Terminação de Peptídeos / Relação Quantitativa Estrutura-Atividade / Ubiquitina-Proteína Ligases / Fator de Transcrição Ikaros / Proteólise Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Terminação de Peptídeos / Relação Quantitativa Estrutura-Atividade / Ubiquitina-Proteína Ligases / Fator de Transcrição Ikaros / Proteólise Idioma: En Ano de publicação: 2018 Tipo de documento: Article