IL-2 prevents deletion of developing T-regulatory cells in the thymus.
Cell Death Differ
; 24(6): 1007-1016, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28362433
ABSTRACT
In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8- CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Transdução de Sinais
/
Interleucina-2
/
Linfócitos T Reguladores
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article