Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata).
J Med Primatol
; 46(3): 93-100, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28369930
ABSTRACT
BACKGROUND:
A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos.METHODS:
The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia.RESULTS:
The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain. Histopathological and immunohistological examinations revealed that the masses were hepatocellular carcinoma (HCC) and a metastatic lesion. In both the primary and metastatic lesions, neoplastic hepatocytes were arranged mainly in a trabecular pattern. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and hepatocyte paraffin 1 and negative for cytokeratin 7 and 20 and vimentin.CONCLUSION:
To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Carcinoma Hepatocelular
/
Macaca
/
Doenças dos Macacos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article