A mock heart engineered with helical aramid fibers for in vitro cardiovascular device testing.
Biomed Tech (Berl)
; 62(2): 139-148, 2017 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-28375841
ABSTRACT
Mock heart circulation loops (MHCLs) serve as in-vitro platforms to investigate the physiological interaction between circulatory systems and cardiovascular devices. A mock heart (MH) engineered with silicone walls and helical aramid fibers, to mimic the complex contraction of a natural heart, has been developed to advance the MHCL previously developed in our group. A mock aorta with an anatomical shape enables the evaluation of a cannulation method for ventricular assist devices (VADs) and investigation of the usage of clinical measurement systems like pressure-volume catheters. Ventricle and aorta molds were produced based on MRI data and cast with silicone. Aramid fibers were layered in the silicone ventricle to reproduce ventricle torsion. A rotating hollow shaft was connected to the apex enabling the rotation of the MH and the connection of a VAD. Silicone wall thickness, aramid fiber angle and fiber pitch were varied to generate different MH models. All MH models were placed in a tank filled with variable amounts of water and air simulating the compliance. In this work, physiological ventricular torsion angles (15°-26°) and physiological pressure-volume loops were achieved. This MHCL can serve as a comprehensive testing platform for cardiovascular devices, such as artificial heart valves and cannulation of VADs.
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Base de dados:
MEDLINE
Assunto principal:
Coração Auxiliar
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Análise de Falha de Equipamento
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Biomimética
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Coração
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Insuficiência Cardíaca
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article