Development of a DNA vaccine expressing a secreted HIV-1 gp41 ectodomain that includes the membrane-proximal external region.

Melnychuk, Luca; Ajamian, Lara; Jean-Pierre, Patrick; Liang, Jiaming; Gheorghe, Romina; Wainberg, Mark A; Zaharatos, Gerasimos J

Melnychuk, Luca; Ajamian, Lara; Jean-Pierre, Patrick; Liang, Jiaming; Gheorghe, Romina; Wainberg, Mark A; Zaharatos, Gerasimos J.

Afiliação

Melnychuk L; Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.
Ajamian L; Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.
Jean-Pierre P; Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada.
Liang J; Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.
Gheorghe R; Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada.
Wainberg MA; Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.
Zaharatos GJ; Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada; Division of Infectious Diseases, Department of Medicine, Jewish General Hospital, Montréal, Québec, Canada. Electronic address: gerasimos.zaharatos@mcgill.ca.

Vaccine ; 35(20): 2736-2744, 2017 05 09.

Article em En | MEDLINE | ID: mdl-28392143

Assuntos

Vacinas contra a AIDS/imunologia; Proteína gp41 do Envelope de HIV/imunologia; HIV-1/imunologia; Vacinas de DNA/imunologia; Vacinas contra a AIDS/administração & dosagem; Vacinas contra a AIDS/genética; Animais; Feminino; Anticorpos Anti-HIV/sangue; Proteína gp41 do Envelope de HIV/genética; HIV-1/genética; Desenvolvimento Humano; Humanos; Camundongos Endogâmicos BALB C; Vacinas de DNA/administração & dosagem; Vacinas de DNA/genética; Vacinas Sintéticas/administração & dosagem; Vacinas Sintéticas/genética; Vacinas Sintéticas/imunologia

Palavras-chave

Broadly neutralizing antibodies; DNA vaccine; HIV-1; Membrane-proximal external region; gp41

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína gp41 do Envelope de HIV / HIV-1 / Vacinas contra a AIDS / Vacinas de DNA Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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