Decreased gene expression of CD2AP in Chinese patients with sporadic Alzheimer's disease.
Neurobiol Aging
; 56: 212.e5-212.e10, 2017 08.
Article
em En
| MEDLINE
| ID: mdl-28392172
ABSTRACT
Many sporadic Alzheimer's disease (SAD) risk genes have been identified in the last decades, but most of them have not been consistently accepted. Here, we sought to identify SAD-associated genes and their potential mechanisms involved in SAD pathogenesis. A 2-stage design was employed. In stage 1, 95 variants in 75 genes that were previously reported as SAD-risk genes in Caucasian populations were evaluated in 1857 subjects (422 SAD patients and 1435 controls). In stage 2, a subset of promising variants found in stage 1 were further evaluated in an independent cohort of 1001 subjects (254 SAD and 747 controls). Variants in CD2AP were significantly associated with SAD risk in our subjects. Furthermore, CD2AP gene expression in peripheral blood lymphocytes (PBL) from 209 SAD patients and 213 controls was determined. CD2AP gene expression in PBL was significantly decreased in patients with SAD as compared with controls. Our study suggests that CD2AP is an SAD-risk gene in Chinese Han population and CD2AP gene expression is decreased in the PBL of patients with SAD, indicating its possible systemic involvement in SAD.
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MEDLINE
Assunto principal:
Variação Genética
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Regulação para Baixo
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Expressão Gênica
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Predisposição Genética para Doença
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Proteínas do Citoesqueleto
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Proteínas Adaptadoras de Transdução de Sinal
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Estudos de Associação Genética
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article