An efficient semi-synthesis of 1-hydroxyl oleanolic acid analogs.
J Asian Nat Prod Res
; 19(6): 595-601, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28393564
An efficient route for the semi-synthesis of either 1α- or 1ß-OH epimers of 1-hydroxy-3-deoxyolean-12-en-28-oic acid (1), 6-8 steps from oleanolic acid is reported. The synthesis involves stereoselective formation of α,ß-unsaturated epoxy ketone and subsequent Wharton reaction as key steps, offering a new access to the 1-O-substituted oleanolic acid-type pentacyclic triterpenoids.
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1
Base de dados:
MEDLINE
Assunto principal:
Ácido Oleanólico
/
Radical Hidroxila
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article