Use of Cortisol and Adrenal Weight at Pediatric Postmortem.
Fetal Pediatr Pathol
; 36(3): 246-255, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28394668
ABSTRACT
We studied the relationship between adrenal weight and postmortem cortisol level in cases of infant death, and examined use of these measurements in adrenal insufficiency. We analyzed procurator-fiscal postmortem reports in the West of Scotland over a three year period. Combined adrenal weight was expressed as percentage of total body weight (%TBW). Of 106 cases, median (5th, 95th) %TBW was 0.056 (0.025, 0.23) and median plasma cortisol was 8.4 ug/dl (1.0, 47.1). There was no correlation between %TBW and plasma cortisol (r = 0.09, p = 0.4). The lowest and highest plasma cortisol quartile had medians of 1.9 ug/dl (1.0, 3.4) and 34.3 ug/dl (17.3, 71.5), respectively. Infection was present in 6 cases (23.1%) in the lowest quartile and in 16 cases (61.5%) in the highest quartile (p = 0.01). Our results highlight the difficulty in interpretation of cortisol at postmortem and suggest that adrenal weight measurement alone may be insufficient for diagnosis of adrenal insufficiency.
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Base de dados:
MEDLINE
Assunto principal:
Morte Súbita do Lactente
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Hidrocortisona
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Glândulas Suprarrenais
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article