Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome.
Stem Cell Res
; 18: 70-72, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-28395810
ABSTRACT
Urine resource cells were collected from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome (MEN1) for generating iPS cells with episomal plasmids. Two stable iPSC lines with free of episomal plasmid were established. The patient has a heterozygous G>T mutation on the exon 9 of Men1 gene that was confirmed by sequencing analysis on all resulted cell lines. Karyotyping indicated the chromosomes with normal appearances and numbers. Their pluripotency was demonstrated by gene expression and their abilities for differentiating into three germ layers. These iPSC lines provide valuable in vitro resources for pathological study on MEN1 syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas
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Neoplasia Endócrina Múltipla Tipo 1
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Células-Tronco Pluripotentes Induzidas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article