Engineering and expressing circular RNAs via tRNA splicing.
RNA Biol
; 14(8): 978-984, 2017 08 03.
Article
em En
| MEDLINE
| ID: mdl-28402213
ABSTRACT
Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo.
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Base de dados:
MEDLINE
Assunto principal:
RNA
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RNA de Transferência
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Precursores de RNA
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Engenharia Genética
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Splicing de RNA
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Sítios de Splice de RNA
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Aptâmeros de Nucleotídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article