Occupational exposure to respirable crystalline silica and chronic non-malignant renal disease: systematic review and meta-analysis.
Int Arch Occup Environ Health
; 90(7): 555-574, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28409224
ABSTRACT
BACKGROUND:
While occupational exposure to respirable silica is known to lead to lung disease, most notably silicosis, its association with chronic kidney disease is unclear.OBJECTIVES:
This review explores the association between occupational exposure to respirable silica and chronic non-malignant renal disease such as glomerulonephritis. The evidence has been collected and compiled. Possible sources of bias are thoroughly discussed.METHODS:
Cohort studies with silica exposure and case-control studies of renal disease were searched in PubMed until January 2015. Two authors independently abstracted data; any disagreement was resolved by consulting a third reviewer. A meta-analysis was performed to evaluate the association to silica exposure.RESULTS:
A total of 23 cohort and four case-control studies were included in the analysis. The meta-analysis of cohort studies yielded elevated overall SMRs for renal disease. Some studies, however, included dose-response analyses, most of which did not show a positive trend. The approaches and results of the case-control studies were very heterogeneous.CONCLUSIONS:
While the studies of cohorts exposed to silica found elevated SMRs for renal disease, no clear evidence of a dose-response relationship emerged. The elevated risk may be attributed to diagnostic and methodological issues. In order to permit a reliable estimation of a possible causal link, exposed cohorts should be monitored for renal disease, as the information from mortality studies is hardly reliable in this field.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Exposição Ocupacional
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Dióxido de Silício
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Exposição por Inalação
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Insuficiência Renal Crônica
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Doenças Profissionais
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article