Reversible synthesis of colanic acid and O-antigen polysaccharides in Salmonella Typhimurium enhances induction of cross-immune responses and provides protection against heterologous Salmonella challenge.

Li, Pei; Liu, Qing; Huang, Chun; Zhao, Xinxin; Roland, Kenneth L; Kong, Qingke

Li, Pei; Liu, Qing; Huang, Chun; Zhao, Xinxin; Roland, Kenneth L; Kong, Qingke.

Afiliação

Li P; Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, USA.
Liu Q; Department of Bioengineering, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address: Qing.liu.2@sicau.edu.cn.
Huang C; Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Zhao X; Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Roland KL; Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, USA.
Kong Q; Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, USA. Electronic address: kongqiki@163

Vaccine ; 35(21): 2862-2869, 2017 05 15.

Article em En | MEDLINE | ID: mdl-28412074

Assuntos

Reações Cruzadas; Imunidade Heteróloga; Antígenos O/biossíntese; Polissacarídeos/biossíntese; Vacinas contra Salmonella/imunologia; Salmonella typhimurium/imunologia; Salmonella typhimurium/metabolismo; Animais; Anticorpos Antibacterianos/sangue; Proteínas da Membrana Bacteriana Externa/imunologia; Feminino; Humanos; Manose-6-Fosfato Isomerase/deficiência; Manose-6-Fosfato Isomerase/metabolismo; Camundongos Endogâmicos BALB C; Antígenos O/imunologia; Fosfotransferases (Fosfomutases)/deficiência; Fosfotransferases (Fosfomutases)/metabolismo; Polissacarídeos/imunologia; Vacinas contra Salmonella/administração & dosagem; Salmonella typhimurium/enzimologia; Vacinas Atenuadas/administração & dosagem; Vacinas Atenuadas/imunologia

Palavras-chave

Colanic acid; Cross-immunity; Live attenuated Salmonella vaccine; Mannose; O-antigen; manB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos / Salmonella typhimurium / Antígenos O / Reações Cruzadas / Vacinas contra Salmonella / Imunidade Heteróloga Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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