Impact of thalamocortical input on barrel cortex development.
Neuroscience
; 368: 246-255, 2018 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-28412498
ABSTRACT
The development of cortical maps requires the balanced interaction between genetically determined programs and input/activity-dependent signals generated spontaneously or triggered from the environment. The somatosensory pathway of mice provides an excellent scenario to study cortical map development because of its highly organized cytoarchitecture, known as the barrel field. This precise organization makes evident even small alterations in the cortical map layout. In this review, we will specially focus on the thalamic factors that control barrel field development. We will summarize the role of thalamic input integration and identity, neurotransmission and spontaneous activity in cortical map formation and early cross-modal plasticity.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Somatossensorial
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Tálamo
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Regulação da Expressão Gênica
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Plasticidade Neuronal
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article