Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion.
Stem Cell Res
; 19: 12-16, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28412999
ABSTRACT
A major cause of spontaneous abortions is chromosomal abnormality of foetal cells. We report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetus with Turner syndrome. The Turner syndrome villus induced pluripotent stem cell line is transgene free, retains the original XO karyotype, expresses pluripotency markers and undergoes trilineage differentiation. This pluripotent stem cell model of Turner syndrome should serve as a tool to study the developmental abnormalities of foetus and placenta that lead to early embryo lethality and profound symptoms like infertility in 45 XO survivors.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Turner
/
Células-Tronco Pluripotentes Induzidas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article