Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics.

Palmu, Kaisa; Rosenqvist, Petja; Thapa, Keshav; Ilina, Yulia; Siitonen, Vilja; Baral, Bikash; Mäkinen, Janne; Belogurov, Georgi; Virta, Pasi; Niemi, Jarmo; Metsä-Ketelä, Mikko

Palmu, Kaisa; Rosenqvist, Petja; Thapa, Keshav; Ilina, Yulia; Siitonen, Vilja; Baral, Bikash; Mäkinen, Janne; Belogurov, Georgi; Virta, Pasi; Niemi, Jarmo; Metsä-Ketelä, Mikko.

Afiliação

Palmu K; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Rosenqvist P; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Thapa K; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Ilina Y; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Siitonen V; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Baral B; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Mäkinen J; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Belogurov G; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Virta P; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Niemi J; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.
Metsä-Ketelä M; Departments of Biochemistry and Chemistry, University of Turku , FIN-20014 Turku, Finland.

ACS Chem Biol ; 12(6): 1472-1477, 2017 06 16.

Article em En | MEDLINE | ID: mdl-28418235

Assuntos

Antibióticos Antineoplásicos/biossíntese; Família Multigênica; Showdomicina/biossíntese; Streptomyces/genética; Proteínas de Bactérias/genética; Biocatálise; Vias Biossintéticas; Genoma Bacteriano/genética; Glicosídeo Hidrolases/genética; Glicosídeo Hidrolases/fisiologia; Nucleosídeos; Análise de Sequência de DNA; Streptomyces/enzimologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Showdomicina / Família Multigênica / Antibióticos Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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