Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study.
J Health Popul Nutr
; 36(1): 12, 2017 04 18.
Article
em En
| MEDLINE
| ID: mdl-28420445
ABSTRACT
OBJECTIVE:
This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population.METHOD:
This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters.RESULTS:
The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups.CONCLUSION:
The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
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População Negra
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Alelos
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Proteína 2 Semelhante ao Fator 7 de Transcrição
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Frequência do Gene
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Genótipo
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Obesidade
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article