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On the in vivo function of the mitral heart valve leaflet: insights into tissue-interstitial cell biomechanical coupling.
Lee, Chung-Hao; Zhang, Will; Feaver, Kristen; Gorman, Robert C; Gorman, Joseph H; Sacks, Michael S.
Afiliação
  • Lee CH; School of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall, Rm. 219C, Norman, OK, 73019, USA.
  • Zhang W; Department of Biomedical Engineering, Center for Cardiovascular Simulation, Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 East 24th St, POB 5.236, 1 University Station, C0200, Austin, TX, 78712, USA.
  • Feaver K; Department of Biomedical Engineering, Center for Cardiovascular Simulation, Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 East 24th St, POB 5.236, 1 University Station, C0200, Austin, TX, 78712, USA.
  • Gorman RC; Department of Biomedical Engineering, Center for Cardiovascular Simulation, Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 East 24th St, POB 5.236, 1 University Station, C0200, Austin, TX, 78712, USA.
  • Gorman JH; Gorman Cardiovascular Research Group, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.
  • Sacks MS; Gorman Cardiovascular Research Group, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Biomech Model Mechanobiol ; 16(5): 1613-1632, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28429161
ABSTRACT
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states. This approach allowed us to make the critical connection between the in vivo functional and the in vitro experimental configurations. Moreover, we incorporated the in vivo MVAL deformations and pre-strains into an enhanced inverse finite element modeling framework (Path 1) to estimate the resulting in vivo tissue prestresses [Formula see text] and the in vivo peak functional tissue stresses [Formula see text]. These in vivo stress estimates were then cross-verified with the results obtained from an alternative forward modeling method (Path 2), by taking account of the changes in the in vitro and in vivo reference configurations. Moreover, by integrating the tissue-level kinematic results into a downscale MVIC microenvironment FE model, we were able to estimate, for the first time, the in vivo layer-specific MVIC deformations and deformation rates of the normal and surgically repaired MVALs. From these simulations, we determined that the placement of annuloplasty ring greatly reduces the peak MVIC deformation levels in a layer-specific manner. This suggests that the associated reductions in MVIC deformation may down-regulate MV extracellular matrix maintenance, ultimately leading to reduction in tissue mechanical integrity. These simulations provide valuable insight into MV cellular mechanobiology in response to organ- and tissue-level alternations induced by MV disease or surgical repair. They will also assist in the future development of computer simulation tools for guiding MV surgery procedure with enhanced durability and improved long-term surgical outcomes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Próteses Valvulares Cardíacas / Valva Mitral Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Próteses Valvulares Cardíacas / Valva Mitral Idioma: En Ano de publicação: 2017 Tipo de documento: Article