Skin score correlates with global DNA methylation and GSTO1 A140D polymorphism in arsenic-affected population of Eastern India.
Toxicol Mech Methods
; 27(6): 467-475, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28436716
ABSTRACT
Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene- and promoter-specific hypermethylation has been reported in different arsenic-exposed cell lines, whereas whole genome DNA methylation study suggested genomic hypo- and hypermethylation after arsenic exposure in in vitro and in vivo studies. Along with other characteristic biomarkers, arsenic toxicity leads to typical skin lesions. The present study demonstrates significant correlation between severities of skin manifestations with their whole genome DNA methylation status as well as with a particular polymorphism (Ala 140 Asp) status in arsenic metabolizing enzyme Glutathione S-transferase Omega-1 (GSTO1) in arsenic-exposed population of the district of Nadia, West Bengal, India.
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MEDLINE
Assunto principal:
Arsênio
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Dermatopatias
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Poluentes Químicos da Água
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Metilação de DNA
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Polimorfismo de Nucleotídeo Único
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Glutationa Transferase
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article