Acute inflammation reveals GABA<sub>A</sub> receptor-mediated nociception in mouse dorsal root ganglion neurons via PGE<sub>2</sub> receptor 4 signaling.

Jang, In Jeong; Davies, Alexander J; Akimoto, Nozomi; Back, Seung Keun; Lee, Pa Reum; Na, Heung Sik; Furue, Hidemasa; Jung, Sung Jun; Kim, Yong Ho; Oh, Seog Bae

Acute inflammation reveals GABA_A receptor-mediated nociception in mouse dorsal root ganglion neurons via PGE₂ receptor 4 signaling.

Jang, In Jeong; Davies, Alexander J; Akimoto, Nozomi; Back, Seung Keun; Lee, Pa Reum; Na, Heung Sik; Furue, Hidemasa; Jung, Sung Jun; Kim, Yong Ho; Oh, Seog Bae.

Afiliação

Jang IJ; Pain Laboratory, Dental Research Institute and Department of Neurobiology and Physiology School of Dentistry Seoul National University, Seoul, Korea.
Davies AJ; Pain Laboratory, Dental Research Institute and Department of Neurobiology and Physiology School of Dentistry Seoul National University, Seoul, Korea.
Akimoto N; Department of Brain and Cognitive Sciences, College of Natural Sciences Seoul National University, Seoul, Korea.
Back SK; Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Lee PR; Department of Physiology, Korea University College of Medicine, Seoul, Korea.
Na HS; Department of Pharmacology and Biotechnology, College of Medical Engineering Konyang University, Daejeon, Korea.
Furue H; Pain Laboratory, Dental Research Institute and Department of Neurobiology and Physiology School of Dentistry Seoul National University, Seoul, Korea.
Jung SJ; Department of Brain and Cognitive Sciences, College of Natural Sciences Seoul National University, Seoul, Korea.
Kim YH; Department of Physiology, Korea University College of Medicine, Seoul, Korea.
Oh SB; Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Japan.

Physiol Rep ; 5(8)2017 Apr.

Article em En | MEDLINE | ID: mdl-28438981

Assuntos

Neurônios GABAérgicos/metabolismo; Nociceptividade; Receptores de GABA-A/metabolismo; Receptores de Prostaglandina E Subtipo EP4/metabolismo; Células Receptoras Sensoriais/metabolismo; Potenciais de Ação; Animais; Sinalização do Cálcio; Células Cultivadas; Dinoprostona/farmacologia; Feminino; Agonistas GABAérgicos/farmacologia; Neurônios GABAérgicos/efeitos dos fármacos; Neurônios GABAérgicos/fisiologia; Gânglios Espinais/citologia; Gânglios Espinais/metabolismo; Gânglios Espinais/fisiologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Muscimol/farmacologia; Canal de Sódio Disparado por Voltagem NAV1.8/metabolismo; Células Receptoras Sensoriais/efeitos dos fármacos; Células Receptoras Sensoriais/fisiologia; Bloqueadores dos Canais de Sódio/farmacologia; Membro 2 da Família 12 de Carreador de Soluto/metabolismo

Palavras-chave

EP4 receptors; Gammaaminobutyric acid; TTXresistant sodium channels; formalin test; peripheral sensitization; prostaglandin E2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Receptoras Sensoriais / Receptores de GABA-A / Receptores de Prostaglandina E Subtipo EP4 / Neurônios GABAérgicos / Nociceptividade Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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