Overcoming Linsitinib intrinsic resistance through inhibition of nuclear factor-&#954;B signaling in esophageal squamous cell carcinoma.

Wu, Junzhou; Chen, Kaiyan; Zhang, Fanrong; Jin, Jiaoyue; Zhang, Nan; Li, Dan; Ying, Lisha; Chen, Wei; Yu, Herbert; Mao, Weimin; Su, Dan

Overcoming Linsitinib intrinsic resistance through inhibition of nuclear factor-κB signaling in esophageal squamous cell carcinoma.

Wu, Junzhou; Chen, Kaiyan; Zhang, Fanrong; Jin, Jiaoyue; Zhang, Nan; Li, Dan; Ying, Lisha; Chen, Wei; Yu, Herbert; Mao, Weimin; Su, Dan.

Afiliação

Wu J; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Chen K; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Zhang F; Department of Oncology, The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Jin J; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Zhang N; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Li D; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Ying L; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Chen W; Department of Oncology, The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Yu H; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Mao W; Cancer Research Institute, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, China.
Su D; Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.

Cancer Med ; 6(6): 1353-1361, 2017 Jun.

Article em En | MEDLINE | ID: mdl-28440057

Assuntos

Antineoplásicos/farmacologia; Carcinoma de Células Escamosas/tratamento farmacológico; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Neoplasias Esofágicas/tratamento farmacológico; Imidazóis/farmacologia; NF-kappa B/antagonistas & inibidores; Fenilenodiaminas/farmacologia; Pirazinas/farmacologia; Apoptose/efeitos dos fármacos; Carcinoma de Células Escamosas/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Neoplasias Esofágicas/metabolismo; Carcinoma de Células Escamosas do Esôfago; MAP Quinases Reguladas por Sinal Extracelular/antagonistas & inibidores; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Humanos; Interleucina-6/genética; Interleucina-8/genética; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Inibidores de Fosfoinositídeo-3 Quinase; RNA Mensageiro/metabolismo; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/metabolismo; Células Tumorais Cultivadas

Palavras-chave

Esophageal cancer; IGF-1R; NF-κB p65; intrinsic resistance; targeted therapy

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilenodiaminas / Pirazinas / Neoplasias Esofágicas / Carcinoma de Células Escamosas / NF-kappa B / Resistencia a Medicamentos Antineoplásicos / Imidazóis / Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google