Control of DNA integrity in skeletal muscle under physiological and pathological conditions.
Cell Mol Life Sci
; 74(19): 3439-3449, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28444416
ABSTRACT
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
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Estresse Oxidativo
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Músculo Esquelético
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Doenças Neuromusculares
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article