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MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.
Nagar, Saumya; Noveral, Sarah M; Trudler, Dorit; Lopez, Kevin M; McKercher, Scott R; Han, Xuemei; Yates, John R; Piña-Crespo, Juan C; Nakanishi, Nobuki; Satoh, Takumi; Okamoto, Shu-Ichi; Lipton, Stuart A.
Afiliação
  • Nagar S; Neuroscience and Aging Research Center and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Noveral SM; Neuroscience and Aging Research Center and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Trudler D; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Lopez KM; Department of Neurosciences and Program in Biomedical Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • McKercher SR; Neuroscience and Aging Research Center and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Han X; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Yates JR; Neuroscience and Aging Research Center and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Piña-Crespo JC; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Nakanishi N; Neuroscience and Aging Research Center and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Satoh T; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Okamoto SI; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Lipton SA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
Proc Natl Acad Sci U S A ; 114(20): E4048-E4056, 2017 05 16.
Article em En | MEDLINE | ID: mdl-28461502
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Células Fotorreceptoras de Vertebrados / Fator 2 Relacionado a NF-E2 Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Células Fotorreceptoras de Vertebrados / Fator 2 Relacionado a NF-E2 Idioma: En Ano de publicação: 2017 Tipo de documento: Article