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The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.
Aldiri, Issam; Xu, Beisi; Wang, Lu; Chen, Xiang; Hiler, Daniel; Griffiths, Lyra; Valentine, Marc; Shirinifard, Abbas; Thiagarajan, Suresh; Sablauer, Andras; Barabas, Marie-Elizabeth; Zhang, Jiakun; Johnson, Dianna; Frase, Sharon; Zhou, Xin; Easton, John; Zhang, Jinghui; Mardis, Elaine R; Wilson, Richard K; Downing, James R; Dyer, Michael A.
Afiliação
  • Aldiri I; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Xu B; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Wang L; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Hiler D; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Griffiths L; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Valentine M; Cytogenetics Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Shirinifard A; Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Thiagarajan S; Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Sablauer A; Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Barabas ME; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Zhang J; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Johnson D; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
  • Frase S; Cell and Tissue Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Easton J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Mardis ER; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63108, USA; Department of Medicine, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63108, USA.
  • Wilson RK; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63108, USA; Siteman Cancer Center, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63108, USA.
  • Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA. Electronic add
Neuron ; 94(3): 550-568.e10, 2017 May 03.
Article em En | MEDLINE | ID: mdl-28472656
In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile the epigenetic and transcriptional changes that occur during retinogenesis in mice and humans. Although some progenitor genes and cell cycle genes were epigenetically silenced during retinogenesis, the most dramatic change was derepression of cell-type-specific differentiation programs. We identified developmental-stage-specific super-enhancers and showed that most epigenetic changes are conserved in humans and mice. To determine how the epigenome changes during tumorigenesis and reprogramming, we performed integrated epigenetic analysis of murine and human retinoblastomas and induced pluripotent stem cells (iPSCs) derived from murine rod photoreceptors. The retinoblastoma epigenome mapped to the developmental stage when retinal progenitors switch from neurogenic to terminal patterns of cell division. The epigenome of retinoblastomas was more similar to that of the normal retina than that of retina-derived iPSCs, and we identified retina-specific epigenetic memory.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retina / Retinoblastoma / Diferenciação Celular / Metilação de DNA / Epigênese Genética / Código das Histonas / Reprogramação Celular / Carcinogênese Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retina / Retinoblastoma / Diferenciação Celular / Metilação de DNA / Epigênese Genética / Código das Histonas / Reprogramação Celular / Carcinogênese Idioma: En Ano de publicação: 2017 Tipo de documento: Article