INPP5D mRNA Expression and Cognitive Decline in Japanese Alzheimer's Disease Subjects.
J Alzheimers Dis
; 58(3): 687-694, 2017.
Article
em En
| MEDLINE
| ID: mdl-28482637
ABSTRACT
Microglial dysfunction and inflammation have recently been shown to be related to the development of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase (INPP5D) functions broadly as a negative regulator of immune signaling, and its locus was associated with development of AD in a large-scale genome-wide association study. Thus, we examined INPP5D mRNA expression and methylation rates of the CpG sites in the upstream region of INPP5D exon 1 in peripheral leukocytes in 50 AD and age- and sex-matched control subjects. INPP5D mRNA expression in AD subjects was significantly higher than that in control subjects (1.16±0.39 versus 1.0±0.23, pâ=â0.049) and was correlated with the Mini-Mental State Examination score (pâ=â0.002, râ=â0.426) and the total score of the Alzheimer's Disease Assessment Scale (pâ<â0.001, râ=â-0.697). Methylation rates in the upstream region of INPP5D exon 1 were not significantly different between AD and control subjects (average rate 3.5±3.0 versus 2.8±1.3, pâ=â0.551). Our results suggested that INPP5D mRNA expression was elevated in the early stage and decreased with cognitive decline in AD. INPP5D mRNA expression in leukocytes may be a useful biomarker for the early stage of AD.
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Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
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Doença de Alzheimer
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Disfunção Cognitiva
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Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatases
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article