Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.
J Nat Prod
; 80(5): 1594-1603, 2017 05 26.
Article
em En
| MEDLINE
| ID: mdl-28489382
ABSTRACT
Two new spirotetronate aglycones, 22-dehydroxymethyl-kijanolide (1) and 8-hydroxy-22-dehydroxymethyl-kijanolide (2), along with seven new spirotetronate glycosides, microsporanates A-F (3-8) and tetrocarcin P (9), together with three known tetrocarcins [tetrocarcins A (10), B (11), and AC6H (12)], were isolated from fermentation broths of the marine-derived Micromonospora harpali SCSIO GJ089. The structures of 1-9 were elucidated on the basis of 1D and 2D NMR and MS spectroscopic data. Compounds 3-8 feature an α,ß-unsaturated carbonyl moiety within their spirotetronate skeletons. Moreover, compounds 3-12 displayed strong to moderate antibacterial activities against Gram positive bacteria Bacillus thuringiensis BT01 and B. subtilis BS01 with MIC values ranging from 0.016 to 8.0 µg/mL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bacillus subtilis
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Glicosídeos
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Aminoglicosídeos
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Anti-Infecciosos
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Micromonospora
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article