Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality.

Jeelani, Roohi; Khan, Sana N; Shaeib, Faten; Kohan-Ghadr, Hamid-Reza; Aldhaheri, Sarah R; Najafi, Tohid; Thakur, Mili; Morris, Robert; Abu-Soud, Husam M

Jeelani, Roohi; Khan, Sana N; Shaeib, Faten; Kohan-Ghadr, Hamid-Reza; Aldhaheri, Sarah R; Najafi, Tohid; Thakur, Mili; Morris, Robert; Abu-Soud, Husam M.

Afiliação

Jeelani R; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Khan SN; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Shaeib F; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Kohan-Ghadr HR; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Aldhaheri SR; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Najafi T; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Thakur M; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA; Division of Genetic, Genomic and Metabolic Disorders, Department of Pediatrics and Center for Molecular Medicine and Genetics, Wayne Stat
Morris R; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA; Karmanos Cancer Institute, Detroit, MI 48201, USA.
Abu-Soud HM; Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address:

Free Radic Biol Med ; 110: 11-18, 2017 09.

Article em En | MEDLINE | ID: mdl-28499912

Assuntos

Acroleína/toxicidade; Antineoplásicos Alquilantes/toxicidade; Ciclofosfamida/toxicidade; Metáfase; Oócitos/efeitos dos fármacos; Espécies Reativas de Oxigênio/agonistas; Acroleína/metabolismo; Animais; Antineoplásicos Alquilantes/metabolismo; Biotransformação; Células do Cúmulo/efeitos dos fármacos; Células do Cúmulo/metabolismo; Células do Cúmulo/patologia; Células do Cúmulo/ultraestrutura; Ciclofosfamida/metabolismo; Relação Dose-Resposta a Droga; Feminino; Injeções Intraperitoneais; Camundongos; Microtúbulos/efeitos dos fármacos; Microtúbulos/metabolismo; Microtúbulos/patologia; Microtúbulos/ultraestrutura; Oócitos/metabolismo; Oócitos/patologia; Oócitos/ultraestrutura; Estresse Oxidativo/efeitos dos fármacos; Cultura Primária de Células; Espécies Reativas de Oxigênio/metabolismo; Fuso Acromático/efeitos dos fármacos; Fuso Acromático/metabolismo; Fuso Acromático/patologia; Fuso Acromático/ultraestrutura

Palavras-chave

Acrolein; Chemotherapy; Chromosome alignment; Cyclophosphamide; Follicle dysfunction; Infertility; Meiotic spindle; Oocyte quality; Oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oócitos / Acroleína / Espécies Reativas de Oxigênio / Antineoplásicos Alquilantes / Ciclofosfamida / Metáfase Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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