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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Zhang, Xianjun; Zhao, Fei; Wu, Yiran; Yang, Jun; Han, Gye Won; Zhao, Suwen; Ishchenko, Andrii; Ye, Lintao; Lin, Xi; Ding, Kang; Dharmarajan, Venkatasubramanian; Griffin, Patrick R; Gati, Cornelius; Nelson, Garrett; Hunter, Mark S; Hanson, Michael A; Cherezov, Vadim; Stevens, Raymond C; Tan, Wenfu; Tao, Houchao; Xu, Fei.
Afiliação
  • Zhang X; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
  • Zhao F; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Wu Y; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Yang J; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Han GW; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
  • Zhao S; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
  • Ishchenko A; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Ye L; Departments of Chemistry, Biological Sciences and Physics &Astronomy, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA.
  • Lin X; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
  • Ding K; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Dharmarajan V; Departments of Chemistry, Biological Sciences and Physics &Astronomy, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA.
  • Griffin PR; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
  • Gati C; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Nelson G; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 555 Zuchongzhi Lu, Building 3, Room 426, Shanghai 201203, China.
  • Hunter MS; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
  • Hanson MA; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Cherezov V; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Stevens RC; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Tan W; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
  • Tao H; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Xu F; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Nat Commun ; 8: 15383, 2017 05 17.
Article em En | MEDLINE | ID: mdl-28513578
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas Hedgehog / Receptor Smoothened / Domínios Proteicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas Hedgehog / Receptor Smoothened / Domínios Proteicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article