The discovery of novel, potent ERR-alpha inverse agonists for the treatment of triple negative breast cancer.

Du, Yongli; Song, Lianhua; Zhang, Liudi; Ling, Hao; Zhang, Yanhui; Chen, Haifei; Qi, Huijie; Shi, Xiaojin; Li, Qunyi

Du, Yongli; Song, Lianhua; Zhang, Liudi; Ling, Hao; Zhang, Yanhui; Chen, Haifei; Qi, Huijie; Shi, Xiaojin; Li, Qunyi.

Afiliação

Du Y; School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, 3501 Daxue Road, Jinan 250353, China. Electronic address: ylduyjs@163.com.
Song L; School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, 3501 Daxue Road, Jinan 250353, China.
Zhang L; Department of Pharmacy, Huashan Hospital North, Fudan University, 108 Luxiang Road, Shanghai 201907, China.
Ling H; School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, 3501 Daxue Road, Jinan 250353, China.
Zhang Y; School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, 3501 Daxue Road, Jinan 250353, China.
Chen H; Department of Pharmacy, Huashan Hospital North, Fudan University, 108 Luxiang Road, Shanghai 201907, China.
Qi H; Department of Pharmacy, Huashan Hospital North, Fudan University, 108 Luxiang Road, Shanghai 201907, China.
Shi X; Department of Pharmacy, Huashan Hospital North, Fudan University, 108 Luxiang Road, Shanghai 201907, China.
Li Q; Department of Pharmacy, Huashan Hospital North, Fudan University, 108 Luxiang Road, Shanghai 201907, China. Electronic address: qyli1234@163.com.

Eur J Med Chem ; 136: 457-467, 2017 Aug 18.

Article em En | MEDLINE | ID: mdl-28525844

Assuntos

Antineoplásicos/farmacologia; Descoberta de Drogas; Nitrilas/farmacologia; Receptores de Estrogênio/metabolismo; Tiazóis/farmacologia; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Humanos; Estrutura Molecular; Nitrilas/síntese química; Nitrilas/química; Relação Estrutura-Atividade; Tiazóis/síntese química; Tiazóis/química; Neoplasias de Mama Triplo Negativas/patologia; Receptor ERRalfa Relacionado ao Estrogênio

Palavras-chave

Antitumor agent; ERR-alpha; Estrogen-related receptor α; Estrogen-related receptor αinverse agonist; FJXTYNUXLXNTMH-UHFFFAOYSA-N; GEKMFGDHSAUEKC-UHFFFAOYSA-N; HTLVBMKJSBOYIQ-UHFFFAOYSA-N; ICQFRKCCKJETDT-UHFFFAOYSA-N; JDNCJZHDKRCMPJ-UHFFFAOYSA-N; KOBGHKYLTVSLKX-UHFFFAOYSA-N; PCLAUUIZRCPWAM-UHFFFAOYSA-N; PUIDQLYMFYPKAE-UHFFFAOYSA-N>; SKMMZUAEYBWKAL-UHFFFAOYSA-N; Triple negative breast cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Receptores de Estrogênio / Descoberta de Drogas / Neoplasias de Mama Triplo Negativas / Antineoplásicos / Nitrilas Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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