Pharmacologic Properties of Novel Local Anesthetic Agents in Anesthesia Practice.
Anesthesiol Clin
; 35(2): 315-325, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28526152
ABSTRACT
Therapeutic duration of traditional local anesthetics when used in peripheral nerve blocks is normally limited. This article describes novel approaches to extend the duration of peripheral nerve blocks currently available or in development. Three newer approaches on extending the duration of peripheral nerve blocks include site-1 sodium channel blockers, novel local anesthetics delivery systems, and novel adjuvants of local anesthetics. Compared with plain amide-based and ester-based local anesthetics, alternative approaches show significant promise in decreasing postoperative pain, rescue opioid requirement, hospital length-of-stay, and overall health care cost, without compromising the established safety profile of traditional local anesthetics.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anestesia
/
Anestésicos Locais
/
Bloqueio Nervoso
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article