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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Quinti, Luisa; Dayalan Naidu, Sharadha; Träger, Ulrike; Chen, Xiqun; Kegel-Gleason, Kimberly; Llères, David; Connolly, Colúm; Chopra, Vanita; Low, Cho; Moniot, Sébastien; Sapp, Ellen; Tousley, Adelaide R; Vodicka, Petr; Van Kanegan, Michael J; Kaltenbach, Linda S; Crawford, Lisa A; Fuszard, Matthew; Higgins, Maureen; Miller, James R C; Farmer, Ruth E; Potluri, Vijay; Samajdar, Susanta; Meisel, Lisa; Zhang, Ningzhe; Snyder, Andrew; Stein, Ross; Hersch, Steven M; Ellerby, Lisa M; Weerapana, Eranthie; Schwarzschild, Michael A; Steegborn, Clemens; Leavitt, Blair R; Degterev, Alexei; Tabrizi, Sarah J; Lo, Donald C; DiFiglia, Marian; Thompson, Leslie M; Dinkova-Kostova, Albena T; Kazantsev, Aleksey G.
Afiliação
  • Quinti L; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Dayalan Naidu S; Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.
  • Träger U; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
  • Chen X; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Kegel-Gleason K; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Llères D; Institute of Molecular Genetics of Montpellier, F-34293 Montpellier, France.
  • Connolly C; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
  • Chopra V; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Low C; Department of Developmental, Molecular and Chemical Biology, Tufts University, Boston, MA 02111.
  • Moniot S; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
  • Sapp E; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Tousley AR; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Vodicka P; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Van Kanegan MJ; Center for Drug Discovery, Duke University Medical Center, Durham, NC 27710.
  • Kaltenbach LS; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710.
  • Crawford LA; Center for Drug Discovery, Duke University Medical Center, Durham, NC 27710.
  • Fuszard M; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710.
  • Higgins M; Department of Chemistry, Boston College, Chestnut Hill, MA 02467.
  • Miller JRC; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
  • Farmer RE; Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.
  • Potluri V; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
  • Samajdar S; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
  • Meisel L; Department of Medicinal Chemistry, Aurigene Discovery Technologies Limited, Bangalore 560 100, India.
  • Zhang N; Department of Medicinal Chemistry, Aurigene Discovery Technologies Limited, Bangalore 560 100, India.
  • Snyder A; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
  • Stein R; Buck Institute for Research on Aging, Novato, CA 94945.
  • Hersch SM; Targanox, Cambridge Research Laboratories, Cambridge, MA 02139.
  • Ellerby LM; Targanox, Cambridge Research Laboratories, Cambridge, MA 02139.
  • Weerapana E; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Schwarzschild MA; Buck Institute for Research on Aging, Novato, CA 94945.
  • Steegborn C; Department of Chemistry, Boston College, Chestnut Hill, MA 02467.
  • Leavitt BR; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
  • Degterev A; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
  • Tabrizi SJ; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
  • Lo DC; Department of Developmental, Molecular and Chemical Biology, Tufts University, Boston, MA 02111.
  • DiFiglia M; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
  • Thompson LM; Center for Drug Discovery, Duke University Medical Center, Durham, NC 27710.
  • Dinkova-Kostova AT; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710.
  • Kazantsev AG; Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114.
Proc Natl Acad Sci U S A ; 114(23): E4676-E4685, 2017 06 06.
Article em En | MEDLINE | ID: mdl-28533375
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Huntington / Fator 2 Relacionado a NF-E2 / Proteína 1 Associada a ECH Semelhante a Kelch Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Huntington / Fator 2 Relacionado a NF-E2 / Proteína 1 Associada a ECH Semelhante a Kelch Idioma: En Ano de publicação: 2017 Tipo de documento: Article