A systematic reactor design approach for the synthesis of active pharmaceutical ingredients.

Emenike, Victor N; Schenkendorf, René; Krewer, Ulrike

Emenike, Victor N; Schenkendorf, René; Krewer, Ulrike.

Afiliação

Emenike VN; Institute of Energy and Process Systems Engineering, Technische Universität Braunschweig, Franz-Liszt-Straße 35, 38106 Braunschweig, Germany; PVZ-Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany; International Max Planck Research School for Advanced Methods in Process and Systems Engineering, Sandtorstraße 1, 39106 Magdeburg, Germany.
Schenkendorf R; Institute of Energy and Process Systems Engineering, Technische Universität Braunschweig, Franz-Liszt-Straße 35, 38106 Braunschweig, Germany; PVZ-Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany.
Krewer U; Institute of Energy and Process Systems Engineering, Technische Universität Braunschweig, Franz-Liszt-Straße 35, 38106 Braunschweig, Germany; PVZ-Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany. Electronic address: u.krewer@tu-braunschweig.de.

Eur J Pharm Biopharm ; 126: 75-88, 2018 May.

Article em En | MEDLINE | ID: mdl-28536050

Assuntos

Química Farmacêutica/métodos; Indústria Farmacêutica/métodos; Preparações Farmacêuticas/síntese química; Química Farmacêutica/instrumentação; Indústria Farmacêutica/instrumentação

Palavras-chave

Active pharmaceutical ingredients; Continuous pharmaceutical manufacturing; Elementary process functions; Intensified reactors; Nucleophilic aromatic substitution; Optimization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Química Farmacêutica / Indústria Farmacêutica Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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