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SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.
Zou, Siying; Teixeira, Alexandra M; Kostadima, Myrto; Astle, William J; Radhakrishnan, Aparna; Simon, Lukas Mikolaj; Truman, Lucy; Fang, Jennifer S; Hwa, John; Zhang, Ping-Xia; van der Harst, Pim; Bray, Paul F; Ouwehand, Willem H; Frontini, Mattia; Krause, Diane S.
Afiliação
  • Zou S; Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Teixeira AM; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Kostadima M; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Astle WJ; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Radhakrishnan A; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Simon LM; Department of Structural and Computational Biology, Baylor College of Medicine, Houston, TX, United States of America.
  • Truman L; Department of ENT, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Fang JS; Yale Cardiovascular Research Center, Department of Cardiology, Yale University School of Medicine, New Haven, CT, United States of America.
  • Hwa J; Yale Cardiovascular Research Center, Department of Cardiology, Yale University School of Medicine, New Haven, CT, United States of America.
  • Zhang PX; Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • van der Harst P; Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Bray PF; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.
  • Ouwehand WH; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
  • Frontini M; Department of Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, United States of America.
  • Krause DS; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
PLoS One ; 12(5): e0178095, 2017.
Article em En | MEDLINE | ID: mdl-28542600
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plaquetas / Polimorfismo de Nucleotídeo Único / Fatores de Troca de Nucleotídeo Guanina Rho Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plaquetas / Polimorfismo de Nucleotídeo Único / Fatores de Troca de Nucleotídeo Guanina Rho Idioma: En Ano de publicação: 2017 Tipo de documento: Article