The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis.
Int J Cancer
; 141(8): 1512-1521, 2017 10 15.
Article
em En
| MEDLINE
| ID: mdl-28542909
ABSTRACT
The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention.
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MEDLINE
Assunto principal:
Herpesvirus Humano 4
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Herpesvirus Humano 8
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Neoplasias
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article