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Analysis on pathogenic and virulent characteristics of the Cronobacter sakazakii strain BAA-894 by whole genome sequencing and its demonstration in basic biology science.
Bao, Xuerui; Yang, Ling; Chen, Lequn; Li, Bing; Li, Lin; Li, Yanyan; Xu, Zhenbo.
Afiliação
  • Bao X; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
  • Yang L; Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
  • Chen L; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
  • Li B; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou, China.
  • Li L; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou, China.
  • Li Y; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address: Yanyanli1123@hotmail.com.
  • Xu Z; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou, China; Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, B
Microb Pathog ; 109: 280-286, 2017 Aug.
Article em En | MEDLINE | ID: mdl-28546117
Cronobacter sakazakii is an opportunistic pathogen responsible for necrotizing enterocolitis, meningitis and septicaemia especially to infant and neonate, with high lethality ranging in 40%-80%. This strain is able to survive in infant milk formula and possesses capability of pathogenicity and virulence, biofilm formation, and high resistance to elevated osmotic, low pH, heat, oxidation, and desiccasion. This study is aims to investigate the molecular characteristics of Cronobacter sakazakii BAA 894, including mechanisms of its invasion and adherence, biofilm formation, unusual resistance to environmental stress employing whole genome sequencing and comparative genomics. Results in this study suggest that numerous genes and pathways, such as LysM, Cyx system, luxS, vancomycin resistance pathway, insulin resistance pathway, and sod encoding superoxide dismutase for the survival of C. sakazakii in macrophages, contribute to pathogenicity and resistance to stressful environment of C. sakazakii BAA 894.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Virulência / Genoma Bacteriano / Cronobacter sakazakii / Sequenciamento Completo do Genoma Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Virulência / Genoma Bacteriano / Cronobacter sakazakii / Sequenciamento Completo do Genoma Idioma: En Ano de publicação: 2017 Tipo de documento: Article