Spermidine promotes <i>Bacillus subtilis</i> biofilm formation by activating expression of the matrix regulator <i>slrR</i>.

Hobley, Laura; Li, Bin; Wood, Jennifer L; Kim, Sok Ho; Naidoo, Jacinth; Ferreira, Ana Sofia; Khomutov, Maxim; Khomutov, Alexey; Stanley-Wall, Nicola R; Michael, Anthony J

Spermidine promotes Bacillus subtilis biofilm formation by activating expression of the matrix regulator slrR.

Hobley, Laura; Li, Bin; Wood, Jennifer L; Kim, Sok Ho; Naidoo, Jacinth; Ferreira, Ana Sofia; Khomutov, Maxim; Khomutov, Alexey; Stanley-Wall, Nicola R; Michael, Anthony J.

Afiliação

Hobley L; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390; Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, United Kingdom.
Li B; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390.
Wood JL; Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, United Kingdom.
Kim SH; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390.
Naidoo J; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390.
Ferreira AS; Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, United Kingdom.
Khomutov M; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
Khomutov A; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
Stanley-Wall NR; Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, United Kingdom. Electronic address: n.r.stanleywall@dundee.ac.uk.
Michael AJ; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390. Electronic address: anthony.michael@utsouthwestern.edu.

J Biol Chem ; 292(29): 12041-12053, 2017 07 21.

Article em En | MEDLINE | ID: mdl-28546427

Assuntos

Bacillus subtilis/fisiologia; Proteínas de Bactérias/agonistas; Biofilmes/crescimento & desenvolvimento; Regulação Bacteriana da Expressão Gênica; Polissacarídeos Bacterianos/biossíntese; Espermidina/metabolismo; Fatores de Transcrição/agonistas; Adenosilmetionina Descarboxilase/genética; Adenosilmetionina Descarboxilase/metabolismo; Bacillus subtilis/citologia; Bacillus subtilis/genética; Bacillus subtilis/crescimento & desenvolvimento; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Cadaverina/análogos & derivados; Cadaverina/metabolismo; Deleção de Genes; Perfilação da Expressão Gênica; Metionina/metabolismo; Metilação; Ciclo do Nitrogênio; Óperon; Purinas/metabolismo; S-Adenosilmetionina/metabolismo; Análise de Célula Única; Espermidina/análogos & derivados; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo

Palavras-chave

Bacillus subtilis; agmatine; aminopropyl; bacteria; biofilm; exopolysaccharide; polyamine; slrR; spermidine; transcriptomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos Bacterianos / Bacillus subtilis / Proteínas de Bactérias / Fatores de Transcrição / Espermidina / Regulação Bacteriana da Expressão Gênica / Biofilmes Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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