Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability.

Utani, Koichi; Fu, Haiqing; Jang, Sang-Min; Marks, Anna B; Smith, Owen K; Zhang, Ya; Redon, Christophe E; Shimizu, Noriaki; Aladjem, Mirit I

Utani, Koichi; Fu, Haiqing; Jang, Sang-Min; Marks, Anna B; Smith, Owen K; Zhang, Ya; Redon, Christophe E; Shimizu, Noriaki; Aladjem, Mirit I.

Afiliação

Utani K; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Fu H; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jang SM; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Marks AB; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Smith OK; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Zhang Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Redon CE; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shimizu N; Graduate School of Biosphere Science, Hiroshima University, Hiroshima 739-8521, Japan.
Aladjem MI; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Nucleic Acids Res ; 45(13): 7807-7824, 2017 Jul 27.

Article em En | MEDLINE | ID: mdl-28549174

Assuntos

Replicação do DNA; Instabilidade Genômica; Origem de Replicação; Sirtuína 1/metabolismo; Linhagem Celular; Quebras de DNA; Replicação do DNA/genética; Células HCT116; Humanos; Células K562; Células MCF-7; Modelos Biológicos; Fosforilação; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Tirosina Quinases/metabolismo; RNA Interferente Pequeno/genética; Sirtuína 1/antagonistas & inibidores; Sirtuína 1/genética; Treonina/química; Quinases Dyrk

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Origem de Replicação / Instabilidade Genômica / Replicação do DNA / Sirtuína 1 Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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