Global approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process.

Netchacovitch, L; Thiry, J; De Bleye, C; Dumont, E; Cailletaud, J; Sacré, P-Y; Evrard, B; Hubert, Ph; Ziemons, E

Netchacovitch, L; Thiry, J; De Bleye, C; Dumont, E; Cailletaud, J; Sacré, P-Y; Evrard, B; Hubert, Ph; Ziemons, E.

Afiliação

Netchacovitch L; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Analytical Chemistry, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium. Electronic address: lnetchacovitch@ulg.ac.be.
Thiry J; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Pharmaceutical Technology and Biopharmacy, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.
De Bleye C; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Analytical Chemistry, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.
Dumont E; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Analytical Chemistry, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.
Cailletaud J; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Analytical Chemistry, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.
Sacré PY; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Analytical Chemistry, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.
Evrard B; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Pharmaceutical Technology and Biopharmacy, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.
Hubert P; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Analytical Chemistry, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.
Ziemons E; University of Liege (ULg), CIRM, Department of Pharmacy, Laboratory of Analytical Chemistry, CHU, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liege, Belgium.