Pubertal Onset in Apparently Healthy Indian Boys and Impact of Obesity.
Indian J Endocrinol Metab
; 21(3): 434-438, 2017.
Article
em En
| MEDLINE
| ID: mdl-28553601
ABSTRACT
OBJECTIVE:
Primary - to determine the age of pubertal onset in Indian boys. Secondary - (a) to assess the impact of obesity on pubertal timing, (b) to assess the relationship between gonadotropins and puberty.DESIGN:
Cross-sectional.SETTING:
General community-seven schools across New Delhi.PARTICIPANTS:
Random sample of 1306 school boys, aged 6-17 years. MATERIALS ANDMETHODS:
Anthropometric measurement for weight and height and pubertal staging was performed for all subjects. Body mass index (BMI) was calculated to define overweight/obesity. Serum luteinizing hormone (LH), follicle stimulating hormone, and serum testosterone were measured in every sixth subject. MAIN OUTCOMEMEASURE:
Age at pubertal onset-testicular volume ≥4 mL (gonadarche) and pubic hair Stage II.RESULTS:
Median age of attaining gonadarche and pubarche was 10.41 years (95% confidence interval [CI] 10.2-10.6 years) and 13.60 (95% CI 13.3-14.0 years), respectively. No significant difference in the age of attainment of gonadarche was observed in boys with normal or raised BMI, though pubarche occurred 8 months earlier in the latter group. Serum gonadotropins and testosterone increased with increasing stages of puberty but were unaffected by BMI. Serum LH level of 1.02 mIU/mL and testosterone level of >0.14 ng/mL showed the best prediction for pubertal onset.CONCLUSION:
The study establishes a secular trend of the age of onset of puberty in Indian boys. Pubarche occurred earlier in overweight/obese boys. The cutoff levels of serum LH and testosterone for prediction of pubertal onset have been established.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article