A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells.
Mol Cell Endocrinol
; 471: 42-50, 2018 08 15.
Article
em En
| MEDLINE
| ID: mdl-28554804
ABSTRACT
Fetal exposure to synthetic glucocorticoids reprograms distinct neural circuits in the developing brain, often in a sex-specific manner, via mechanisms that remain poorly understood. To reveal whether such reprogramming is associated with select molecular signatures, we characterized the transcriptome of primary, embryonic mouse cerebral cortical and hypothalamic neural progenitor/stem cells derived from individual male and female embryos exposed to the synthetic glucocorticoid, dexamethasone. Gene expression profiling by RNA-Seq identified differential expression of common and unique genes based upon brain region, sex, and/or dexamethasone exposure. These gene expression datasets provide a unique resource that will inform future studies examining the molecular mechanisms responsible for region- and sex-specific reprogramming of the fetal brain brought about by in utero exposure to excess glucocorticoids.
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Base de dados:
MEDLINE
Assunto principal:
Dexametasona
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Córtex Cerebral
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Caracteres Sexuais
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Embrião de Mamíferos
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Células-Tronco Neurais
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Transcriptoma
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Hipotálamo
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article