Differential neuronal susceptibility and apoptosis in congenital Zika virus infection.
Ann Neurol
; 82(1): 121-127, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28556287
ABSTRACT
To characterize the mechanism of Zika virus (ZIKV)-associated microcephaly, we performed immunolabeling on brain tissue from a 20-week fetus with intrauterine ZIKV infection. Although ZIKV demonstrated a wide range of neuronal and non-neuronal tropism, the infection rate was highest in intermediate progenitor cells and immature neurons. Apoptosis was observed in both infected and uninfected bystander cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis. Our results highlight differential neuronal susceptibility and neuronal apoptosis as potential mechanisms in the development of ZIKV-associated microcephaly, and may provide insights into the design and best timing of future therapy. Ann Neurol 2017;82121-127.
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Base de dados:
MEDLINE
Assunto principal:
Feto
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Infecção por Zika virus
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Neurônios
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article