Mitochondria link metabolism and epigenetics in haematopoiesis.

Schell, John C; Rutter, Jared

Schell, John C; Rutter, Jared.

Afiliação

Schell JC; Department of Biochemistry and Howard Hughes Medical Institute, University of Utah School of Medicine, 15 North Medical Drive East, Room 5520A, Salt Lake City, Utah 84112-5650, USA.
Rutter J; Department of Biochemistry and Howard Hughes Medical Institute, University of Utah School of Medicine, 15 North Medical Drive East, Room 5520A, Salt Lake City, Utah 84112-5650, USA.

Nat Cell Biol ; 19(6): 589-591, 2017 May 31.

Article em En | MEDLINE | ID: mdl-28561053

ABSTRACT

ABSTRACT

Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

Assuntos

Epigênese Genética; Hematopoese/genética; Mitocôndrias/metabolismo; Animais; Células-Tronco Hematopoéticas/metabolismo; Humanos; Modelos Biológicos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Hematopoese / Mitocôndrias Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Hematopoese / Mitocôndrias Idioma: En Ano de publicação: 2017 Tipo de documento: Article